LIFE SCIENCE

Detailed explanation-1: -Doxorubicin (Adriamycin), a topoisomerase II (Top2)-targeting drug, is one of the most effective anticancer drugs used in the clinic.

Detailed explanation-2: -It represents an appropriate, but nonselective target for anticancer therapy. Topoisomerase inhibitors in current use in the United States include irinotecan and topotecan, inhibitors of topoisomerase I, and etoposide and teniposide, inhibitors of topoisomerase II.

Detailed explanation-3: -As discussed above, doxorubicin can inhibit topoisomerase II in the cleaved form and thus directly cause double-strand breaks. However, as a DNA intercalator, doxorubicin primarily alters DNA topology.