OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What enzyme keeps DNA from overwinding ahead of replication forks?
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Primase
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Topoisomerase
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Single-Stand Binding Protein
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Helicase
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Explanation:
Detailed explanation-1: -Topoisomerase prevents the over-winding of the DNA double helix ahead of the replication fork as the DNA is opening up; it does so by causing temporary nicks in the DNA helix and then resealing it.
Detailed explanation-2: -Topoisomerase is an enzyme involved in DNA replication that relaxes supercoiled DNA ahead of the replication fork so that replication may proceed.
Detailed explanation-3: -Topoisomerases play critical roles in DNA replication, transcription, and chromosome structure by altering the topological state of DNA, . These enzymes are capable of relaxing supercoiled DNA and of decatenating interlocked DNA (Fig. 3.3. 1).
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