LIFE SCIENCE

Detailed explanation-1: -A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of chromosomal translocations can be important for the diagnosis of certain genetic diseases and disorders.

Detailed explanation-2: -Translocations. A translocation occurs when a piece of one chromosome breaks off and attaches to another chromosome. This type of rearrangement is described as balanced if no genetic material is gained or lost in the cell.

Detailed explanation-3: -Although reciprocal translocations can arise by crossing over during homologous recombination, most translocations appear to arise by NHEJ [4, 5].

Detailed explanation-4: -Recombination can occur between any two genes on a chromosome, the amount of crossing over is a function of how close the genes are to each other on the chromosome. If two genes are far apart, for example at opposite ends of the chromosome, crossover and non-crossover events will occur in equal frequency.