OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What is the effect of a nucleotide-pair substitution that results in a nonsense mutation in a gene?
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it changes an amino acid in the encoded protein
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It has no effect on the amino acid sequence of the encoded protein
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it introduces premature stop codon into the mRNA
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it alters the reading frame of the mRNA
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Explanation:
Detailed explanation-1: -What is the effect of a nucleotide-pair substitution that results in a nonsense mutation in a gene? It alters the reading frame of the mRNA. It introduces a premature stop codon into the mRNA.
Detailed explanation-2: -Nonsense mutations occur due to the substitution of a single base pair in a triplet codon, leading to one of three stop codons (UAG, UAA, and UGA). The triplet codon coding for an amino acid is therefore altered to one that prematurely stops mRNA translation and results in a truncated protein.
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