OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What is the function of the poly-A tail in mRNA?
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to add modified guanin to the 3’ end of the mRNA
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to indicate the site of translational termination
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to code for the binding of RNA polymerase to the DNA
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to help protect the mRNA from degradation by hydrolytic enzymes
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Explanation:
Detailed explanation-1: -The growing poly(A) tails favor RNase R degradation. In the presence of poly(A) tails RNase R can easily overcome the RNA secondary structure and completely degrade the rpsO mRNA. RNase R is therefore established as a major poly(A)-dependent exonuclease involved in the degradation of the rpsO mRNA.
Detailed explanation-2: -Poly(A) Polymerase catalyzes the incorporation of adenine residues into the 3’ termini of RNA, effectively adding a poly(A) tail to RNA. The enzyme uses single-stranded RNA as a primer during poly(A) tailing.
Detailed explanation-3: -The 5-methylguanosine cap and the poly(A) tail both contribute to protect eukaryotic mRNAs against degradation.
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