OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What is the role of DNA ligase enzyme in Replication?
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Sealing of nucleotides nicks/gaps
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Synthesis of DNA strand
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Lagging strand synthesis
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All of the above
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Explanation:
Detailed explanation-1: -DNA ligases play an essential role in maintaining genomic integrity by joining breaks in the phosphodiester backbone of DNA that occur during replication and recombination, and as a consequence of DNA damage and its repair.
Detailed explanation-2: -The size and position of the gaps and the deletions were equivalent, confirming that T4 DNA ligase was sealing the gaps.
Detailed explanation-3: -T4 DNA ligase can seal a nick in double-stranded DNA limited by a 5’-phosphorylated base-free deoxyribose residue.-PMC.
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