OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Nucleus
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RNAse
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Spliceosome
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ribozymes
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Detailed explanation-1: -2006; Ward and Cooper 2010). Nuclear pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. Both the conformation and composition of the spliceosome are highly dynamic, affording the splicing machinery its accuracy and at the same time flexibility.
Detailed explanation-2: -Pre-mRNA splicing. Splicing of a pre-mRNA molecule occurs in several steps that are catalyzed by small nuclear ribonucleoproteins (snRNPs). After the U1 snRNP binds to the 5′ splice site, the 5′ end of the intron base pairs with the downstream branch sequence, forming a lariat.
Detailed explanation-3: -The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing.