OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It might substitute a different amino acid in the active site.
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It might exchange one serine codon for a different serine codon.
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It might result in a chromosomal translocation.
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None of the above
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Detailed explanation-1: -Why might a point mutation in DNA make a difference in the level of a protein’s activity? It might substitute a different amino acid in the active site. The genetic code is essentially the same for all organisms.
Detailed explanation-2: -Missense Mutation A missense mutation is a DNA change that results in different amino acids being encoded at a particular position in the resulting protein.
Detailed explanation-3: -Point mutations with highly polar and charged amino acids increases the misfold/unfold propensity of proteins. Substitution of natural amino acids at sites with different number of nonbonded contacts suggests that both amino acid identity and its respective site-specificity determine the stability of a protein.
Detailed explanation-4: -A point mutation in a DNA make a difference in the level of the proteins activity because it might substitute the n terminus of the polypeptide chain for the c-terminus.