Antibodies in skin, mucosa of GI tract, respiratory tract, and tonsils. Binds to and activates mast cells and basophils that trigger inflammatory and allergic responses.

SIGNALLING IMMUNOLOGY CANCER

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	IgM
B	IgA
C	IgD
D	IgG
E	IgE

Explanation:

Detailed explanation-1: -However, it is thought that the most crucial function of IgE in allergic diseases is its ability to sensitize mast cells to release biologically active mediators in an antigen-specific manner.

Detailed explanation-2: -Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.

Detailed explanation-3: -IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions.

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LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

SIGNALLING IMMUNOLOGY CANCER