OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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IgM
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IgA
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IgD
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IgG
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IgE
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Detailed explanation-1: -IgM is the first class of immunoglobulin made by B cells as they mature, and it is the form most commonly present as the antigen receptor on the B-cell surface. When IgM is secreted from the cells, five of the basic Y-shaped units become joined together to make a large pentamer molecule with 10 antigen-binding sites.
Detailed explanation-2: -IgD receptors regulate peripheral B cell immunity and tolerance. IMMUNITY. Immature B cells expressing surface IgM but not IgD differentiate into transitional B cells.
Detailed explanation-3: -Expression of the membrane-bound form of the immunoglobulin (Ig) as part of the antigen receptor is indispensable for both the development and the effector function of B cells. Among five known isotypes, IgM and IgD are the common B cell antigen receptors (BCRs) that are co-expressed in naïve B cells.