OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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During T-cell dependent activation, which of the following is the LAST signal the B-cell receives before proliferation?
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Cytokines signaling by T-Cell
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MHC/BCR binding of same antigen
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Binding of free floating antigen
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Binding of antigen on APC
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Explanation:
Detailed explanation-1: -Activation of naive CD8 T cells to undergo clonal expansion and develop effector function requires three signals: (a) Ag, (b) costimulation, and (c) IL-12 or adjuvant.
Detailed explanation-2: -B cell activation is dependent on the sequential integration of at least two signals. The first signal is generated by BCR cross-linking with antigen; the second is provided by interaction of B cells with T-helper cells (Parker, 1993).
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