OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Activated B-Cell; B-cell growth & differentiation
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Activated CD4-cells; Stimulates differentiation of B-cells & Eosinophils; Promotes IgA & IgE
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Activated B-Cell; Inhibits cytokine synthesis; down-regulates cellular response; enhances immunoglobulin secretion
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Macrophages; Chemoattracts neutrophils; promotes neutrophil adherence to vascular endothelial cells
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Detailed explanation-1: -Interleukin 6 (IL-6) is a multifunctional cytokine that is produced in a variety of clinical situations associated with inflammation. IL-6 was originally isolated and cloned as a B-cell differentiation factor that induced terminal B-cell differentiation and supported the production of immunoglobulin G (IgG).
Detailed explanation-2: -TNF- and IL-1 also activate transcription factors to produce IL-6.
Detailed explanation-3: -Once B-cells are activated, they become plasma cells that produce antibodies in response to an antigen. Or they become memory cells that remember the antigen so your immune system can quickly identify and fight it in the future.
Detailed explanation-4: -Interleukin-6 The cytokine known as IL-6 was originally characterized as B-cell growth factor (e.g., B-cell stimulatory factor 2) based on its ability to induce the differentiation of activated B cells toward antibody-secreting plasma cells, and as IFN-B2 due to an intrinsic antiviral action [78].