LIFE SCIENCE

Detailed explanation-1: -CD8+ T cells recognize antigens in the form of short peptide fragments bound to major histocompatibility complex class I (MHCI) molecules on the target cell surface.

Detailed explanation-2: -The TCRs of CD8 T lymphocytes bind very loosely to most peptide–MHC I–peptide combinations but with much higher affinity to a small subset. This specificity is acquired during the development of the CD8 T lymphocyte in the thymus.

Detailed explanation-3: -The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target cells is required for effective T cell activation.