OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
MHC I binds to which cell?
|
CD8 T cells
|
|
CD4 T cells
|
|
B Cells
|
|
APC
|
Explanation:
Detailed explanation-1: -CD8+ T cells recognize antigens in the form of short peptide fragments bound to major histocompatibility complex class I (MHCI) molecules on the target cell surface.
Detailed explanation-2: -The TCRs of CD8 T lymphocytes bind very loosely to most peptide–MHC I–peptide combinations but with much higher affinity to a small subset. This specificity is acquired during the development of the CD8 T lymphocyte in the thymus.
Detailed explanation-3: -The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target cells is required for effective T cell activation.
There is 1 question to complete.