OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Name the cytokine:Co-stimulates TH cell activation, Promotes T-cell proliferation (stimulates IL-2 receptors); inflammation
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IL-1
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IL-3
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IL-4
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IL-6
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Explanation:
Detailed explanation-1: -Cytokines stimulate switching of antibody isotypes in B cells, differentiation of helper T cells into Th-1 and Th-2 subsets, and activation of microbicidal mechanisms in phagocytes.
Detailed explanation-2: -We have shown here that DCs as well as DC-derived cytokines (TNF-, IL-6, IL-10, and IL-12) promote T cell proliferation in response to c-cytokines.
Detailed explanation-3: -IL-6. IL-6 promotes T cell proliferation, the differentiation of cytotoxic T lymphocyte populations, and, when present in combination with TGF-, promotes Th-17 development. Preclinical studies of IL-6 in GVHD and GVL confirm its key role as a pathogenic cytokine in GVHD.
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