LIFE SCIENCE

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OBJECTIVE LIFE SCIENCE

SIGNALLING IMMUNOLOGY CANCER

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Place the steps of first exposure cell mediated immunity in order. cytotoxic T-Cells enter circulation and search for antigen displacying cells, attack and destroy the antigen either directly or indirectly production of more helper T cells, cytotoxic cells, memory T-Cells, and B-Cellsclones of memory T-cells remain in lymphatic tissue and Lymph nodes suppressor T-Cells appear when antigen destroyedhelper T-cells bind to antigen and macrophage and lymphokines releasedAntigen engulfed by marcrophage, ID’ed, and monokines are released
A
1, 2, 3, 4, 5, 6
B
5, 6, 3, 4, 2, 1
C
6, 5, 2, 1, 4, 3
D
4, 1, 3, 6, 2, 5
Explanation: 

Detailed explanation-1: -There are three stages during T cells activation by DCs, namely antigen presenting, antigen recognition of T cells and two signals formation. In addition, IS formation between T cells and DCs plays an important role in T cell activation.

Detailed explanation-2: -Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) anti-gen recognition, (2) costimulation, and (3) cytokine-mediated differentiation and expansion.

Detailed explanation-3: -Cognitive Phase. In the cognitive step, the macrophages display antigens on the surface. Activation Phase. In the activation step, T-cells with CD4 receptors interact with the MHC-II complex. Effector Phase. In the last stage, activated immune cells carry out phagocytosis and cytolysis. 01-Apr-2022

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