LIFE SCIENCE

Detailed explanation-1: -APCs interact with T cells to link innate and adaptive immune responses. By displaying bacterial and tumorigenic antigens on their surface via major histocompatibility complexes, APCs can directly influence the differentiation of T cells.

Detailed explanation-2: -In the WP, splenic naïve and central memory T cells are activated in response to cognate antigen and T-dependent B cell germinal center (GC) reactions resulting in antibody production (8). Inside the WP, compartmentalization separates the T and B cell areas into distinct zones, analogous to those found in LNs (Fig.

Detailed explanation-3: -In the spleen, T cells are passively released in the blood flow from the arterioles in the red pulp and marginal zone area. In contrast, T cells in the blood are actively captured on high endothelial venules in lymph nodes by the coordinated actions of CCR7 and several adhesion molecules.