OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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MHCI
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MHCII
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TCR
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BCR
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Detailed explanation-1: -Naïve CD8 T cells become activated when they recognize peptide antigen bound to MHC I at the surface of bone marrow–derived pAPCs. In contrast to other cells, pAPCs produce cytokines and express costimulatory molecules that are important for optimal CD8 T cell activation.
Detailed explanation-2: -CD8 is shown in purple (2) and yellow () binding mainly to the 3 domain of MHCI (indicated by an arrow).
Detailed explanation-3: -Cytotoxic CD8 T cells carry out their killing function by releasing two types of preformed cytotoxic protein: the granzymes, which seem able to induce apoptosis in any type of target cell, and the pore-forming protein perforin, which punches holes in the target-cell membrane through which the granzymes can enter.