OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What occurs during class switching?
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Change in the constant region of the heavy chain
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Change in both the heavy and light chains
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Change in the variable region of the light chain
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Change of the disulphide bonds of the hinge region
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Explanation:
Detailed explanation-1: -Class switching occurs by a deletional recombination between two different switch (S) regions, each of which is associated with a heavy chain constant (CH) region gene. Class switch recombination (CSR) is instigated by activation-induced cytidine deaminase (AID), which converts cytosines in S regions to uracils.
Detailed explanation-2: -Class switch recombination (CSR) occurs between switch (S) regions located upstream of each of the CH regions except C and results in a change from IgM and IgD expression by naive B cells to expression of one of the downstream isotypes.
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