OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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GM-CSF
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TH2
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Either A or B
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None of the above
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Detailed explanation-1: -G-CSF (Neupogen or Filgrastim), granulocyte-colony stimulating factor, is a glycoprotein that has multiple functions in both physiological and pathophysiological conditions. G-CSF stimulates the BM to produce granulocytes and stem cells and release them into the bloodstream.
Detailed explanation-2: -The CSF family includes: G-CSF stimulates the production of polymorphonuclear (PMN ) leukocytes, which are necessary for the ingestion and intracellular destruction of bacteria. It is often used to increase neutrophil numbers and decrease infections in patients with non-myeloid malignancies.
Detailed explanation-3: -GM-CSF has been found to promote the proliferation and differentiation of CMPs into the granulocytes and macrophages (GM) lineage (Fig. 1). Once formed, the GM lineage cells differentiate into the uni-lineage monocytes committed progenitors (MP) or the unilineage granulocytes committed progenitors (GP).