LIFE SCIENCE

Detailed explanation-1: -Once activated, mast cells secrete numerous vasoactive and pro-inflammatory mediators [37-42]. These include pre-formed molecules such as histamine, serotonin, TNF, kinins and proteases stored in secretory granules.

Detailed explanation-2: -Most commonly the receptors on the mast cells are TLRs and receptors for complement. Once the antigen binds to the receptors on the mast cell, it causes the release of inflammatory mediators, which helps to eliminate the pathogen that activated it.

Detailed explanation-3: -What is Mast Cell Activation Syndrome. MCAS is a chronic condition involving multiple organs in which normal mast cell activation leads to the inflammation and allergic symptoms that may occur episodically in patients. Gastrointestinal symptoms are common including Irritable Bowel Syndrome.