LIFE SCIENCE

Detailed explanation-1: -One of the best-known chemical mediators released from cells during inflammation is histamine, which triggers vasodilation and increases vascular permeability.

Detailed explanation-2: -Basophils secrete two types of chemicals that aid in body defenses: histamines and heparin. Histamines are responsible for dilating blood vessels and increasing their permeability in inflammation.

Detailed explanation-3: -Histamine is a major preformed mediator released by mast cells and it strongly increases vascular permeability. This increase in vascular permeability is responsible for several features of acute allergic reactions including edema, urticaria, and anaphylactic shock in serious cases.

Detailed explanation-4: -The inflammatory response (inflammation) occurs when tissues are injured by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals including histamine, bradykinin, and prostaglandins. These chemicals cause blood vessels to leak fluid into the tissues, causing swelling.