OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which is the general mechanism behind peripheral tolerance of T cells?
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Antigen sequestration
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Clonal anergy
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Clonal deletion
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T-regulatory cells
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Explanation:
Detailed explanation-1: -Peripheral tolerance. T-cell anergy is induced by inhibiting mTOR pathways or can be induced by tolerogenic DCs.
Detailed explanation-2: -T cell clonal anergy is a proposed mechanism of immunologic self tolerance in which T cells become functionally inactivated after previous stimulation. MHC class II-restricted antigen presentation by different cell types has been speculated to have a role in determining activation vs. anergy in responding T cells.
Detailed explanation-3: -Dendritic cells (DCs) participate in the negative selection of autoreactive T cells in the thymus, but they also mediate peripheral immune tolerance through several mechanisms.
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