OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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intestinal smooth muscle contraction
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suppression of mast cell degranulation
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increased vascular permeability
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increased mucous secretion
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all of the answers result from histamine binding H1
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Detailed explanation-1: -Histamine works with nerves to produce itching. In food allergies it can cause vomiting and diarrhea. And it constricts muscles in the lungs, making it harder to breathe. Most worrisome is when histamine causes anaphylaxis, a severe reaction that is potentially fatal.
Detailed explanation-2: -Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.
Detailed explanation-3: -Immediate hypersensitivity Within minutes of skin contact by an antigen, the mast cells release histamine and other factors, causing an inflammatory reaction.