OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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V-J, Heavy chain
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D-J, Heavy chain
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V-DJ, Light chain
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V-J, light chain
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Detailed explanation-1: -VDJ rearrangement occurs during the maturation of B cells. VDJ rearrangement on ‘H’ chain occurs in Pro-B cells to produce Heavy chain. VJ rearrangement on ‘L’ chain occurs in Precursor B cells to produce Light chain.
Detailed explanation-2: -VDJ rearrangement is a process by which the genes responsible for encoding the variable region of the B-cell receptor and T-cell receptor are rearranged to create a diverse repertoire of receptors capable of recognizing a wide variety of antigens.
Detailed explanation-3: -In adult humans, it is expressed in pro-B cells but its expression declines at the pre-B cell stage, when heavy-chain gene rearrangement is complete and light-chain gene rearrangement has commenced.