OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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first generation
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second generation
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Either A or B
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None of the above
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Detailed explanation-1: -Second-generation H1 antihistamines such as cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine cross the blood-brain barrier to a significantly smaller extent than their predecessors. The clinical pharmacology, efficacy, and safety of these medications have been extensively studied.
Detailed explanation-2: -There are reports based on patient-rated questionnaires [19, 20] that show that even second-generation antihistamines, such as rupatadine and cetirizine, especially if up-dosed, lead to daytime sleepiness nonetheless.
Detailed explanation-3: -Loratadine, cetirizine, and fexofenadine are the most commonly prescribed second-generation antihistamines. Many tests have been conducted to assess the central effects of these three drugs.