MCQ IN MEDICINE

Detailed explanation-1: -These thyroid follicles act as storage compartments filled with a substance called the colloid. This colloid is thyroglobulin, which is nothing but acidophilic secretory glycoprotein that is PAS-positive.

Detailed explanation-2: -The follicles are lined with follicular cells and are filled with a fluid known as colloid that contains the prohormone thyroglobulin. The follicular cells contain the enzymes needed to synthesize thyroglobulin, as well as the enzymes needed to release thyroid hormone from thyroglobulin.

Detailed explanation-3: -Thyroglobulin is the most abundant protein in the thyroid gland, and the protein backbone for synthesis of T3 and T4 hormones. The most stable form of Tg is a 660 kDa glycoprotein built of two chains (12S forms), 330 kDa each [68].

Detailed explanation-4: -Thyroglobulin is an essential substrate for organification and is the major protein component of the colloid in the thyroid follicular lumen. It is an iodinated glycoprotein with a molecular weight approximating 650, 000 daltons.