MCQ IN MEDICINE

Detailed explanation-1: -Hypersegmentation. The presence of hypersegmented neutrophils is an important diagnostic feature of megaloblastic anaemias. Neutrophil hypersegmentation can be defined as the presence of neutrophils with six or more lobes or the presence of more than 3% of neutrophils with at least five lobes.

Detailed explanation-2: -A normal neutrophil has up to three to four segments in its nucleus, and a hypersegmented neutrophil has six or greater.

Detailed explanation-3: -A normal neutrophil granulocyte is characterized by the number of nuclear lobes (segments) in the range of two to five. Normally, 10% to 30% of segmented neutrophils have two lobes; the three-lobe type contributes to 40% to 50%, and 10% to 20% are four-lobe type. Five-lobe type constitutes of less than 5%.