MCQ IN MEDICINE

Detailed explanation-1: -The spleen, lymph nodes, kidneys, liver, bone marrow, and other viscera may also contain large amounts of smallpox virus. Incubation periods are typically 10-12 days but can range from 7-17 days.

Detailed explanation-2: -Smallpox can be deadly if the virus attacks the circulatory system, bone marrow or respiratory system. As recently as the 1960s, around 12 million people caught this highly contagious disease and approximately two million people died every year.

Detailed explanation-3: -The variola virus is a large brick-shaped particle that measure about 300 by 250 by 200 nm. The virion contains an envelope, a surface membrane, a concave core and two lateral bodies. The envelope of the virus is made of modified Golgi membranes that contain viral-specific polypeptides, including hemagglutinin.

Detailed explanation-4: -About a day after infection of the liver and spleen, large numbers of virions are liberated into the bloodstream, leading to secondary infection of the skin, kidneys, lungs, intestines, and other organs.

Detailed explanation-5: -People who had smallpox had a fever and a distinctive, progressive skin rash. Most people with smallpox recovered, but about 3 out of every 10 people with the disease died. Many smallpox survivors have permanent scars over large areas of their body, especially their faces. Some are left blind.