MEDICINE MCQ
INFECTIOUS DISEASES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Why has it proved difficult to develop a vaccine against malaria?
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Mosquitoes have many stages in thier life cycle.
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The parasite are only vulnerable to atttack when outide the liver and red blood cells.
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The human immune system doesnot recognise the antigens of the parasite.
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Vaccines are repidly broken down by proteases in stomach.
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Explanation:
Detailed explanation-1: -To evade the human immune system and enter red blood cells, a normally active gene in the malaria parasite nucleus goes into silent state-then switches back to active state when immunity wanes.
Detailed explanation-2: -One of the key limitations for the success of malaria vaccines is the difficulty in maintaining durable protection after immunization, which in part has been ascribed to poorly immunogenic antigens as well as to the effect of malaria itself in suppressing host responses.
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