MEDICAL PHYSIOLOGY

Detailed explanation-1: -Fibrin is the insoluble fibrous protein formed from fibrinogen, a soluble protein. Fibrin forms a mesh-like or jelly-like substance at the injury site and ultimately, the blood clot is formed when the red blood cells get entangled with the mesh-like substance.

Detailed explanation-2: -Fibrin is essential for clot contraction because it propagates the platelet-generated contractile forces through the entire network that comprises a clot or thrombus. The structure and rheological properties of fibrin gels are important because they determine the degree of platelet-mediated contraction.