MEDICAL PHYSIOLOGY

Detailed explanation-1: -Secondary hemostasis involves the clotting factors acting in a cascade to ultimately stabilize the weak platelet plug. This is accomplished by completing three tasks: (1) triggering activation of clotting factors, (2) conversion of prothrombin to thrombin, and (3) conversion of fibrinogen to fibrin.

Detailed explanation-2: -During coagulation, fibrinogen is converted into insoluble fibrin (Figure 1). Fibrin formation involves thrombin-mediated proteolytic cleavage and removal of N-terminal fibrinopeptides from the A and B chains.

Detailed explanation-3: -When blood clotting is activated, fibrinogen circulating in the blood is converted to fibrin, which in turn helps to form a stable blood clot at the site of vascular disruption. Coagulation inhibitor proteins help to prevent abnormal coagulation (hypercoagulability) and to resolve clots after they are formed.