PHYSIOLOGY
BLOOD PHYSIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Low levels of oxygen in blood
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Normal levels of hemoglobin in RBCs
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A high RBC count
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An increased blood flow through the kidneys
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Detailed explanation-1: -Polycythemia vera can also lead to low levels of EPO. Polycythemia vera is a type of blood cancer that causes your bone marrow to make too many red blood cells due to a genetic mutation. It causes low EPO levels because your kidneys sense that you have enough red blood cells, so they don’t produce as much EPO.
Detailed explanation-2: -The kidneys and liver produce erythropoietin when oxygen levels in the cells are low. The hormone then stimulates the bone marrow, which, in turn, makes more red blood cells.
Detailed explanation-3: -Erythropoietin (EPO) is a glycoprotein hormone, naturally produced by the peritubular cells of the kidney, that stimulates red blood cell production. Renal cortex peritubular cells produce most EPO in the human body. PO2 directly regulates EPO production. The lower the pO2, the greater the production of EPO.