MEDICAL PHYSIOLOGY

PHYSIOLOGY

CARDIOVASCULAR PHYSIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the role of fibrin in blood clotting?
A
acts as an enzyme
B
forms a mesh of fibres to cover the wound
C
causes smooth muscles in blood vessels to contract
D
starts off the whole process
Explanation: 

Detailed explanation-1: -They change shape from round to spiny, stick to the broken vessel wall and each other, and begin to plug the break. They also interact with other blood proteins to form fibrin. Fibrin strands form a net that entraps more platelets and blood cells, producing a clot that plugs the break.

Detailed explanation-2: -Fibrin plays an important role in the body for blood clotting; when injury occurs, a soluble precursor to fibrin, called fibrinogen, is cleaved by a protease called thrombin. Fibrin fibers then are cross-linked to form an interlacing, insoluble mesh, known as a clot.

Detailed explanation-3: -An essential function during coagulation is the platelet-mediated consolidation of clots in a process known as clot contraction (or retraction). This process involves fibrin(ogen) binding to platelet integrin receptor IIbB3 and is influenced by both platelet and fibrin(ogen) concentrations.

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