MEDICAL PHYSIOLOGY

PHYSIOLOGY

CENTRAL NERVOUS SYSTEM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
How much of a change in the membrane potential is necessary for the summation of postsynaptic potentials to result in an action potential being generated?
A
+30mV
B
+15mV
C
+10mV
D
-15mV
Explanation: 

Detailed explanation-1: -In order to generate an action potential, the membrane potential must reach the threshold, which is usually around-55 mV.

Detailed explanation-2: -Excitatory Postsynaptic Potentials (EPSPs) This change is called a depolarization because the cell’s membrane potential is moving toward 0 mV, and the membrane is becoming less polarized.

Detailed explanation-3: -Summation of postsynaptic potentials occurs when a presynaptic neuron fires repeatedly at a high rate (“temporal summation”) or when several presynaptic terminals fire at the same time (“spatial summation”) or from a combination of temporal and spatial summation.

Detailed explanation-4: -R is the universal gas constant (8.314 J.K-1. T is the temperature in Kelvin (°K = °C + 273.15). z is the ionic charge for an ion. F is the Faraday’s constant (96485 C. [X]out is the concentration of the ion outside of the species. More items •15-Aug-2020

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