MEDICAL PHYSIOLOGY

Detailed explanation-1: -The movement disorder arises due to the loss of dopaminergic neurons of the substantia nigra pars compacta, with the pathological hallmark being intracellular aggregates of -synuclein, in the form of Lewy bodies and Lewy neurites.

Detailed explanation-2: -A loss of the dopaminergic neurons of the substantia nigra leads to Parkinson disease, and the symptoms of this disease can be treated using dopamine-supplementation approaches.

Detailed explanation-3: -Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the appearance of intracellular inclusions, named Lewy bodies and Lewy neurites in the remaining nigral neurons.