PHYSIOLOGY
CENTRAL NERVOUS SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Increase in concentration of Na ions
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binding of a neurotransmitter
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increase in concentration of K ions
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depolarization of the membrane
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Detailed explanation-1: -The channels are opened, or gated, by the binding of a neurotransmitter to an orthosteric site(s) that triggers a conformational change that results in the conducting state. Modulation of gating can occur by the binding of endogenous, or exogenous, modulators to allosteric sites.
Detailed explanation-2: -Neurotransmitter-gated ion channels, also known as ionotropic receptors, are responsible for fast synaptic transmission. They decode chemical signals into electrical responses, thereby transmitting information from one neuron to another.
Detailed explanation-3: -Binding of the neurotransmitter opens the ligand-gated ion channels, resulting in graded potentials. Positive charged ions move downward and negative charged ions move upward the channel.