A 10-year old boy consumes a cheeseburger, fries, and chocolate shake. The meal stimulates the release of several gastrointestinal hormones. The presence of fat, carbohydrate, or protein in the duodenum stimulates the release of which of the following hormones from the duodenal mucosa?

GASTROINTESTINAL PHYSIOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	Cholecytokinin (CCK)
B	Glucose-dependent insulinotropic peptide (GIP)
C	Gastrin
D	Secretin
E	Motilin

Explanation:

Detailed explanation-1: -During meal ingestion, the main hormone responsible for stimulating acid secretion is gastrin, which acts primarily by releasing histamine from enterochromaffin-like cells.

Detailed explanation-2: -The presence of fat, such as oleate, in the meal results in stimulation of cholecystokinin (CCK) secretion in the duodenum; in turn, this inhibits antral motility, stimulates pyloric tone and delays gastric emptying [8]. CCK is the first of a repertoire of hormones that regulate gastric emptying.

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