An atrophy of the gastric mucosa causes a decrease in the production of the intrinsic factor of vit B12, which can produce:

GASTROINTESTINAL PHYSIOLOGY

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	iron deficiency anemia
B	Sickle cell anaemia.
C	Anemia megaloblastica.
D	Thalassemia.

Explanation:

Detailed explanation-1: -Pernicious anemia is a complex disease, with a clear autoimmune basis. The anemia is megaloblastic and is caused by vitamin B12 deficiency secondary to intrinsic factor (IF) deficiency.

Detailed explanation-2: -Pernicious anemia is a type of vitamin B12 anemia. The body needs vitamin B12 to make red blood cells. You get this vitamin from eating foods such as meat, poultry, shellfish, eggs, and dairy products. A special protein, called intrinsic factor (IF), binds vitamin B12 so that it can be absorbed in the intestines.

Detailed explanation-3: -Core tip: Chronic atrophic autoimmune gastritis is an autoimmune disease characterized by progressive parietal cells destruction leading to hypochlorhydria and intrinsic factor deficiency. These alterations may result in vitamin B12 deficiency and iron malabsorption.

There is 1 question to complete.