MEDICAL PHYSIOLOGY

Detailed explanation-1: -ICC generate spontaneous electrical slow waves and transmit these waves to smooth muscle cells in the gut to generate phasic contractions and peristalsis. Absence or reduction in the number of ICC or alteration of their structure has a dramatic effect on GI motility.

Detailed explanation-2: -Interstitial cells of Cajal of the deep muscular plexus (ICC-DMP) are the cell types found in the deep muscular plexus. These multipolar cells are associated closely with the nerve bundles of the deep muscular plexus.

Detailed explanation-3: -Specialized cells known as interstitial cells of Cajal (ICC) are distributed in specific locations within the tunica muscularis of the gastrointestinal tract and serve as electrical pacemakers, active propagation pathways for slow waves, and mediators of enteric motor neurotransmission.

Detailed explanation-4: -Interstitial cells of Cajal generate electrical slow waves in the murine stomach-PMC.