MEDICAL PHYSIOLOGY

Detailed explanation-1: -If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley.

Detailed explanation-2: -What is celiac disease? Celiac disease is an inherited autoimmune disorder that causes a reaction in your body to the protein, gluten. Gluten in your digestive system triggers your immune system to produce antibodies against it. These antibodies damage the lining of your small intestine (the mucosa).

Detailed explanation-3: -Celiac disease is associated with an inappropriate immune response to a segment of the gluten protein called gliadin . This inappropriate activation of the immune system causes inflammation that damages the body’s organs and tissues and leads to the signs and symptoms of celiac disease.

Detailed explanation-4: -If you have coeliac disease, the mucosa (lining) of your small intestine is damaged. This causes inflammation of the villi, referred to as villous atrophy. As a result of this inflammation, the surface area of your small intestine, which enables the absorption of nutrients and minerals, is seriously reduced.