MEDICAL PHYSIOLOGY

PHYSIOLOGY

GASTROINTESTINAL PHYSIOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Which of the following hormones is released by the presence of fat and protein in the small intestine and has major effect to decrease gastric emptying?

A	Cholecystokinin (CCK)
B	Gastrin
C	Glucose Dependent Insulinotorphic Peptide (GIP)
D	Secretin

Explanation:

Detailed explanation-1: -The presence of fat, such as oleate, in the meal results in stimulation of cholecystokinin (CCK) secretion in the duodenum; in turn, this inhibits antral motility, stimulates pyloric tone and delays gastric emptying [8]. CCK is the first of a repertoire of hormones that regulate gastric emptying.

Detailed explanation-2: -Cholecystokinin (CCK) is produced by discrete endocrine cells in the proximal small intestine and is released following the ingestion of food. CCK is the primary hormone responsible for gallbladder contraction and has potent effects on pancreatic secretion, gastric emptying, and satiety.

Detailed explanation-3: -Secretin is secreted from S cells in the duodenum in response to H+ and fatty acids in the lumen. Specifically, a pH less than 4.5 signals arrival of gastric contents, which initiates the release of secretin.

Detailed explanation-4: -Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled.

There is 1 question to complete.