MEDICAL PHYSIOLOGY

Detailed explanation-1: -Somatostatin is known to inhibit gastric acid secretion via both inhibition of histamine release from gastric enterochromaffin-like cells and direct inhibition of parietal cell function.

Detailed explanation-2: -Somatostatin produces predominantly neuroendocrine inhibitory effects across multiple systems. It is known to inhibit GI, endocrine, exocrine, pancreatic, and pituitary secretions, as well as modify neurotransmission and memory formation in the CNS.

Detailed explanation-3: -Gastric delta cells (D-cells), which are somatostatin-secreting cells, are the main paracrine inhibitor of acid secretion.

Detailed explanation-4: -Somatostatin thus lowers gastrin secretion and hydrochloric acid production, while in the small intestines it lowers the secretion of a number of other gastrointestinal hormones, thus inhibiting transit time and bile acid production.