MEDICAL PHYSIOLOGY

Detailed explanation-1: -As these cells move further towards the surface of the skin, they get bigger and flatter and adhere together, and then eventually become dehydrated and die. This process results in the cells fusing together into layers of tough, durable material, which continue to migrate up to the surface of the skin.

Detailed explanation-2: -This death occurs largely as a result of the distance the keratinocytes find themselves from the rich blood supply the cells of the stratum basale lie on top off. Devoid of nutrients and oxygen, the keratinocytes die as they are pushed towards the surface of our skin.

Detailed explanation-3: -Cells are pushed into stratum granulosum and become flattened and diamond shaped. The cells accumulate keratohyalin granules mixed between tonofibrils. Cells continue to stratum corneum where they flatten and lose organelles and nuclei.

Detailed explanation-4: –3-the stratum granulosum: here the keratinization process begins and the cells begin to die. This layer is called granulosum because the cells contain granules of the precursor of keratine.

Detailed explanation-5: -Stratum Spinosum and Granulosum This layer gets its name from the fact that the cells located here contain many granules. The keratinocytes produce a lot of keratin in this layer-they become filled with keratin. This process is known as keratinization.