MEDICAL PHYSIOLOGY

Detailed explanation-1: -Osteoblasts are cuboidal cells that are located along the bone surface comprising 4–6% of the total resident bone cells and are largely known for their bone forming function [22].

Detailed explanation-2: -Osteoblasts, osteocytes and osteoclasts are the three cell types involved in the development, growth and remodeling of bones. Osteoblasts are bone-forming cells, osteocytes are mature bone cells and osteoclasts break down and reabsorb bone. There are two types of ossification: intramembranous and endochondral.

Detailed explanation-3: -Osteoblasts, bone lining cells and osteoclasts are present on bone surfaces and are derived from local mesenchymal cells called progenitor cells.

Detailed explanation-4: -Osteoblasts are cells that form bone tissue. Osteoblasts can synthesize and secrete bone matrix and participate in the mineralization of bone to regulate the balance of calcium and phosphate ions in developing bone. Osteoblasts are derived from osteoprogenitor cells.

Detailed explanation-5: -Osteoblasts group into clusters and form an ossification center. Osteoblasts begin secreting osteoid, an unmineralized collagen-proteoglycan matrix that can bind calcium.