MEDICAL PHYSIOLOGY

Detailed explanation-1: -Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions. However, when the balance is disturbed, bone architecture or function will be abnormal.

Detailed explanation-2: -Osteoblasts themselves also play a crucial role in initiation of bone resorption since osteoblast precursor cells produce RANKL, which stimulates osteoclast differentiation [22].

Detailed explanation-3: -Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood.

Detailed explanation-4: -Osteoclasts are involved in bone resorption that contributes to bone remodelling in response to growth or changing mechanical stresses upon the skeleton. Osteoclasts also participate in the long-term maintenance of blood calcium homeostasis.

Detailed explanation-5: -Increased bone resorption is an important determinant in a pathophysiology of osteoporosis and many other metabolic bone diseases. Osteoclasts are cells of hematopoietic origin that are responsible for bone resorption.