Substance produced by basophils and mast cells that causes vasodilation and increases vascular permeability.

GENERAL PHYSIOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	thyroxine
B	insulin
C	histamine
D	hormone

Explanation:

Detailed explanation-1: -Histamine is a major preformed mediator released by mast cells and it strongly increases vascular permeability.

Detailed explanation-2: -Histamine is produced in basophils and mast cells and involved in inflammatory responses. Histamine increases the permeability of the capillaries to white blood cells in the infected tissue.

Detailed explanation-3: -Injured tissue mast cells release histamine, causing the surrounding blood vessels to dilate and increase in permeability.

Detailed explanation-4: -Histamine is a vasodilatory substance released during anaphylaxis.

Detailed explanation-5: -Histamine is a major secretory product of the mast cell and is recognized for its role in the regulation of vasodilation and bronchoconstriction (115, 116). Histamine also regulates functions of monocytes and macrophages (117, 118), eosinophils (117, 118), T cells (119), neutrophils, and endothelial cells (120, 121).

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