MEDICAL PHYSIOLOGY

Detailed explanation-1: -Toxicity. Beta-carotene doesn’t seem to be toxic in large doses. But high doses over a long time can lead to carotenemia. This causes your skin to become yellowish orange.

Detailed explanation-2: -Carotene is a lipochrome that normally adds yellow color to the skin. With elevated blood levels of carotene, the prominence of this yellowing is increased. Carotenemia may be particularly evident when the stratum corneum is thickened or when the subcutaneous fat is strongly represented.

Detailed explanation-3: -We found evidence that health-related skin color variation is attributable to carotenoid pigments (which affect skin yellowness) and is unrelated to melanin (which affects skin lightness).

Detailed explanation-4: -High intakes of beta-carotene do not cause the same problems as preformed vitamin A. Consuming high amounts of beta-carotene can turn the skin yellow-orange, but this condition is harmless and goes away when you eat less of it.