MEDICAL PHYSIOLOGY

Detailed explanation-1: -In striated muscle cells, myosin forms the backbone of the thick filaments, which are anchored within the M-band and extend bidirectionally toward the two opposite ends of the sarcomere (171, 247).

Detailed explanation-2: -Definition. noun, plural: thick filaments. A type of myofilament that is made up of bipolar myosin II filaments, and is approximately 12-14 nm in diameter.

Detailed explanation-3: -Thick and thin filaments, which comprise the myofilaments, are composed primarily of the proteins myosin and actin, respectively, and the light band of the sarcomere is the portion where only thin filaments are present and the dark band is where both thick and thin filaments are present.