MEDICAL PHYSIOLOGY

Detailed explanation-1: -The release of acetylcholine occurs when an action potential is relayed and reaches the axon terminus in which depolarization causes voltage-gated calcium channels to open and conduct an influx of calcium, which will allow the vesicles containing acetylcholine for release into the synaptic cleft.

Detailed explanation-2: -The space between the two is known as the synaptic cleft.

Detailed explanation-3: -The motor end plate possesses junctional folds-folds in the sarcolemma that create a large surface area for the neurotransmitter to bind to receptors. The receptors are actually sodium channels that open to allow the passage of Na+ into the cell when they receive a neurotransmitter signal.

Detailed explanation-4: -The acetylcholine binds to the nicotinic receptors concentrated on the motor end plate, a specialized area of the muscle fibre’s post-synaptic membrane. This binding causes the nicotinic receptor channels to open and let sodium ions enter the muscle fibre.

Detailed explanation-5: -Acetylcholine is a small molecule that acts as a chemical messenger to propagate nerve impulses across the neuromuscular junction between a nerve and a muscle. When the nerve impulse from a motor neuron arrives at the tip of its axon, acetylcholine molecules stored there in vesicles are released into the synaptic gap.