MEDICAL PHYSIOLOGY

PHYSIOLOGY

GENERAL PHYSIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the name of the neurotransmitter that is released from the neuron to the sarcolemma?
A
Acetylcholine
B
Acetone
C
ATP
D
Calcium
Explanation: 

Detailed explanation-1: -In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma.

Detailed explanation-2: -Cholinergic neurons that release acetylcholine, an excitatory neurotransmitter, are widely distributed in the central nervous system.

Detailed explanation-3: -Acetylcholine binds to receptors on the sarcolemma. Sodium, potassium, and other cations begin to flow across the cell membrane, generating an action potential within the muscle fiber. The muscle contracts.

Detailed explanation-4: -Acetylcholine binds to specialized receptors (ligand-gated channels) at the postsynaptic terminal (sarcolemma). The opening of these channels causes an influx of Na+ ions into the cell, leading to the threshold potential and the generation of end-plate potential at the neuromuscular junction (Figure 6).

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